James Sethna > Sloppy Models > NGF/EGF signaling through Erk

NGF/EGF signaling through Erk

Code and data

Model equations:
- PDF
- LaTeX
- C
- SBML (systems biology markup language)
Model parameters:
- Best-fit parameters
- Parameter ensemble chosen to fit experimental data
Sensitivity analysis:
- Best-fit JtJ, its eigenvalues and eigenvectors
Download all [tar.gz]

More information

Original paper: "The Statistical Mechanics of Meta-Models: Nerve Growth Factor Signaling", Kevin S. Brown, Colin C. Hill, Guillermo A. Calero, Kelvin H. Lee, James P. Sethna, and Richard A. Cerione
Online supplementary material for original paper

Model cartoon

Automatically generated illustration of implementation

Current best fit to data

Erk1HYaoEGF.expt.png

Erk1HYaoNGF.expt.png

ErkMekTraverse2EGF.expt.png

ErkMekTraverse2NGF.expt.png

ErkMekTraverseHERover.expt.png

Raf1BrafLandrethNGF.expt.png

Raf1LandrethEGF.expt.png

Rap1YorkNGF.expt.png

RasGreen1EGF.expt.png

RasGreen1NGF.expt.png

Last modified May 19, 2008

Statistical Mechanics: Entropy, Order Parameters, and Complexity, now available at Oxford University Press (USA, Europe).